Alex Kolicich of 8VC dishes on China, VC Dumb Money, Inflections in Biotech, Nvidia's Moat, and more

Investing in China, then and now; life at Clarium Capital; the real liquidity crisis; and the 'Adapt or Die' moment for biotech

, Founding Partner at 8VC, digs deep on China, VC now and later, liquidity non-problems, the benefits of generalist investing, cross-pollination between the asset classes, Nvidia’s moat (and where it ends), and a lot more.

Alex is a fascinating guy, who worked at Palantir and Google, before joining Peter Thiel at Clarium Capital as a macro investor, and then later Venture Capital with Joe Lonsdale at 8VC.

The original prompt for the conversation was this essay that Alex wrote on Tariffs, Tech and Tactics: The Era of Strategic Competition with China, but we expanded the mission.

Show notes below


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Competition with China, tariff policy that would actually make sense, the Adapt-or-Die moment for Biotech, and Dumb Money in VC

00:00 Intro and Bio for Alex Kolicich of 8VC

01:38 How did predictions about China perform?

06:28 Investing in China going forward (or not)

09:37 Consumption Patterns and Government Policies in China

11:09 China's Strategic Economic Decisions

13:23 A Tariff Policy That Would Actually Make Sense

18:52 China's Biotech Industry and Fast Follower Strategy

22:02 US Biotech Industry Must Adapt or Die

28:14 What really matters in AI development and competition, the DeepSeek Moment, and Inference is Where It's At

31:21 Where Nvidia's moat ends, and where AMD and Huawei go next

35:52 Current Venture Capital Landscape, Not All Liquidity Issues are Created Equal, Roles for SMID-Cap Investors

37:55 Revenue Multiples and Market Dynamics

40:29 The Case for Going Public

43:34 What's really going on in Secondary Markets?

47:18 Who is to blame for companies staying private longer

49:49 A class of non-hyper growth companies has emerged, but investors have no plan

53:26 Dumb Money in Venture Capital, in AI, and the Correction Hasn't Even Started, Yet

56:27 Venture going forward, the bifurcation, challenges for Emerging Managers, etc.

59:50 Will new VC-Adjacent Strategies Emerge, What made Clarium Capital different

01:04:22 Silicon Valley has a deep ignorance of finance, and other opportunities for Cross-Pollination between the asset classes

01:05:40 The Advantages of Being a Generalist


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